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KMID : 0895820220320040001
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Journal of Oriental Rehabilitation Medicine
2022 Volume.32 No. 4 p.1 ~ p.8
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Anti-Obesity Effects of Gastrodia elata Extracts on High Fat Diet-Induced Obese Mice
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Kim Ye-Seul
Kim Ha-Rim
Park Eun-Hee
Song Young-Eun
Kim Chang-Su
Ha Won-Bae
Woo Hyeon-Jun
Han Yun-Hee
Lee Jung-Han
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Abstract
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Objectives This study is to investigate the effects and mechanisms of Gastrodia elata extract (GEE) on the high-fat diet-induced obesity model.
Methods C57BL/6 mice were randomly assigned into 5 groups (n=10). Control group was fed normal diet (ND). Obesity group was fed 60% high fat diet (HFD). The other three groups were fed HFD with 100, 200, 500 mg/kg GEE. After five weeks, body weight, liver and epididymal fat weight, triglyceride concentration in liver and serum, sterol regulatory element-binding protein-1 (SREBP-1), acetyl-CoA carboxylase (ACC), fatty acid synthase, peroxisome proliferator-activated receptor γ (PPAR-γ), CCAAT/enhancer binding protein α (C/EBP-α) expression level, insulin concentration in serum were measured.
Results The GEE (100, 200, and 500 mg/kg)-treated animals exhibited substantial decreases in body mass, liver weight and epididymal white adipose tissue collate to the HFD-fed group. GEE treatment also reduced hepatic and serum triglyceride level. Furthermore, GEE treatment significantly inhibited adipogenesis in the GEE group by reducing the protein expression of SREBP-1, ACC and the messenger RNA expression of PPARγ, C/EBP-α, which are adipocyte differentiation-related genes.
Conclusions These research outcomes recommend that GEE is possibly valuable for the prevention of HFD-induced obesity via modification of various pathways related with adipogenesis and adipocyte differentiation.
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KEYWORD
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Gastrodia elata extract, Obesity, High-fat diet, Adipogenesis
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